Vladimir G. Kukes

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Vladimir G Kukes
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Professor Vladimir Grigoryevich Kukes, Russia

Prof. Vladimir G. Kukes started his professional activities as a medical doctor in far eastern city of Russia — Magadan as a part of obligatory practical studies. After coming back to Moscow he continued his internal medicine studies and became interested in the new filed of clinical pharmacology. He went to listen to the first lectures in clinical pharmacology by professor Votchal in the Russian State Academy of Physicians’ Excellence.

His dissertation was dedicated to the studies of mechanisms of action of diuretics in heart failure. He defended it and received a degree of a candidate of medical sciences in 1964. After that he continued to study pathology and effects of drugs in heart failure, and rather soon — in 1970 — defended the highest scientific degree in Russia — doctor of medical sciences on the studies in functional characteristics of neural and endocrine systems in heart failure.

exc. from the nomination letter. You will find the document as a PDF download below.
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[wm_item title=”Nomination Letter”]

Dear Colleagues,

On behalf of the national Russian Society of clinical pharmacologists I would like to present professor Vladimir Kukes as a nominee for the lifetime achievement award in clinical pharmacology.

His name is well known and respected in all parts of Russia, he is considered a pioneer and founder of national clinical pharmacology combining brilliant qualities in research, organizational work, teaching.

Vladimir Kukes was born on 8, September 1934 in Leningrad. He is a doctor of medical sciences since 1970, professor since 1974, associate member since 1974 and full member since 1999 of the Russian Academy of Sciences (highest research governing organization in Russia), honored researcher of Russia since 1995, head of the department of clinical pharmacology and introduction into internal diseases at the 1a Moscow Medical State University n.a. I.M.Sechenov, director of the Center of clinical pharmacology of the Ministry of Health.

After graduation from the 15t Moscow Medical University in 1957 he started his professional activities as a medical doctor in far eastern city of Russia — Magadan as a part of obligatory practical studies. After coming back to Moscow he continued his internal medicine studies and became interested in the new filed of clinical pharmacology. He went to listen to the first lectures in clinical pharmacology by professor Votchal in the Russian State Academy of Physicians’ Excellence.

His dissertation was dedicated to the studies of mechanisms of action of diuretics in heart failure. He defended it and received a degree of a candidate of medical sciences in 1964. After that he continued to study pathology and effects of drugs in heart failure, and rather soon — in 1970 — defended the highest scientific degree in Russia — doctor of medical sciences on the studies in functional characteristics of neural and endocrine systems in heart failure.

At the same time his interest in clinical pharmacology and brilliant organizational abilities made it possible for him to establish the first in the USSR laboratory for pharmacokinetic studies, he became a head of this laboratory in 1969. His laboratory became a basis for education of many future clinical pharmacologists from other parts of Russia.

In 1971 he initiated establishment of the first in the USSR division of clinical pharmacology. In 1979 he established first educational courses in clinical pharmacology, in 1985 the courses and the division were reorganized into the department of clinical pharmacology, which is headed by professor Kukes since then until now.

He initiated development of the first curricula in clinical pharmacology, he wrote a number of textbooks for students: textbook for medical students in internal diseases, 2 editions: 1981, 1986 (translated to Spanish); textbook for medical students “Clinical pharmacology”, which has for the moment survived 5 editions (1991, 1999, 2003, 2006, 2008, 2014), textbook for pharmaceutical students “Clinical pharmacology andpharmacotherapy” (2003, 2008, 2013), practice guidelines in clinical pharmacology (2011, 2013), authored the first in Russia national position paper on “Medical specialty of clinical pharmacology”.

He was a principal mentor in 25 doctoral (highest scientific degree in Russia) and over 113 candidate of medical sciences (relative equivalent of PhD) dissertations. His students have formed currently active brilliant society of specialists in clinical pharmacology, they are professors of clinical pharmacology in various medical universities in Russia and abroad, who in turn they are mentors for over 50 candidate of medical sciences and 10 doctoral dissertations in clinical pharmacology. Former students of professor Kukes work not only in all parts of Russia, but in other countries of the Commonwealth of Independent States, China, Taiwan, Iran, Morocco.

His main research projects have been bridging fundamental science and clinical practice. He was the first scientist in Russia to promote concept of personalized medicine combining studies of pharmacokinetics, pharmacogenetics, therapeutic and adverse effects.

He has developed many methods of measurement of drug concentrations in biological fluids, provided evidence for performing relevant tests to predict individual response to medications. He was the first to initiate research projects in drug metabolism and biorhythms in relation to drug effects, developed methods of geno- and phenotyping of biotransformation enzymes and drug transporters, studied their clinical significance, drug-drug and drug-food interactions.

Professor Kukes is still actively promoting concept of personalized medicine — pharmacogenetic testing, evaluation of P450 enzymes activity and drug transporters in clinical practice to provide personalized use of drugs especially in the treatment of most relevant diseases. He is leading research projects in search of drugs modulating activity of the enzymes and transporters. He also paid attention to the ethnical minorities, and initiated research projects studying pharmacogenetics in populations of separated areas of Russia so that they could benefit from personalized medical treatments. He developed new algorithms of pharmacogenetic testing and their implementation in clinical practice, which lead to rather wide spread of these types of testing provided for many patients in Russia by clinical pharmacologists, and promoted concept of personalized medicine.

Professor Kukes has made a lot in development of national pharmaceutical industry as well. He participated in the development of several drugs and wrote national guidelines for quality of preclinical and clinical studies.

Professor Kukes has published over 400 research papers mostly in Russian, but also in international journals. He has published 21 monographs, 52 guidelines and textbooks for students and doctors, he is an author of 16 patented inventions. His textbooks have survived more than 8 editions and are translated into Spanish and Kazakh languages.

He has many professional governmental awards and medals for his achievements in establishments and development of clinical pharmacology in Russia.

He has been collaborating with many colleagues abroad, and not only he promoted clinical pharmacology in Russia, but also in countries of the Commonwealth of Independent States. He has been an active member of the EACPT collaborating with leaders in clinical pharmacology: professors Michael Orme, Folke Sjoqvist, Ingolf Cascorbi, lvar Roots, Vitan Vlahov and others.

I can conclude that professor Kukes has been active in establishment and promotion of all major areas in clinical pharmacology — healthcare, teaching and research. Thanks to his efforts clinical pharmacology was for the first time in Russia and earlier than in many other countries defined as an official medical specialty in 1997, clinical pharmacologists started to work in real clinical settings. He developed first textbooks in clinical pharmacology and made it an obligatory subject in the curricula for medical students across Russia in 1982. He also promoted quality standards in preclinical and clinical studies of new drugs, and co-authored in national guidelines for preclinical and clinical studies. He initiated first laboratory services in clinical pharmacology in different Russian cities.

He successfully negotiated with governments as a director of the Center of clinical pharmacology at the Research Center of Expertise of Medical Devices and Medicines, Ministry of Health, member of the national formulary committee as well as a member of the Russian Academy of Medical Sciences, which lead to incorporation of clinical pharmacology in official healthcare, education, and research.

He spread principles and knowledge in clinical pharmacology through extensive research collaboration and education of numerous students from all parts of Russia and abroad.

The all-Russian association of clinical pharmacologists asks you to consider professor Kukesas a worthy candidate for the EACPT lifetime achievement award.

Sincerely,
Professor Vladimir Petrov,
President of the Russian association of clinical pharmacologists,
Full member of the Russian Academy of Medical Sciences
Chief clinical pharmacologist in the Ministry of Health
Rector at the Volgograd State Medical University

view original nomination letter

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[wm_item title=”Curriculum Vitae”]

Vladimir Grigoryevich KUKES

Born 08 September 1934 Leningrad, USSR (now St. Petersburg, Russia)

Title and/or Degrees

Professor (of internal diseases), MD

1957 Medical diploma, 1st Moscow Medical Institute n.a.I.M.Sechenov
1957-1960 Practical studies in internal medicine, Magadan hospital (Far East)
1961-1964 Postgraduate studies department of introduction into internal diseases, candidate of medical sciences (euquivalent of PhD) 1st Moscow Medical Institute n.a.I.M.Sechenov
1961-1970 Studies of clinical pharmacology (first lectures by prof. Votchal, Central Institute of medical doctors’ excellence)
1964-1971 Teaching assistant, department of introduction into internal diseases 1st Moscow Medical Institute n.a.I.M.Sechenov
1969 Founder and head of the first in Russia laboratory of pharmacokinetics
1971 Founder and head of the first in Russia division of clinical pharmacology
1974 Associate member of Russian Academy of Sciences
1974 Doctor of medical sciences degree, 1st Moscow Medical Institute n.a.I.M.Sechenov
1974 Professor of internal diseases
1979 Founder and head of the first in Russia teaching course of clinical pharmacology (later (1985) transformed into the department of clinical pharmacology)
1985 – currently Head of the department of clinical pharmacology and introduction into internal medicine, 1st Moscow Medical Institute n.a.I.M.Sechenov
1993 – currently Full member of the Russian Academy of Sciences
1999 Meritorious worker of science
1999-2015 Director of the Center of clinical pharmacology at the Research Center of Expertise of Medical Devices and Medicines, Ministry of Health
2005 Founder of the first laboratory of pharmacogenetics in Russia
2006 Honorary professor 1st Moscow Medical Institute n.a.I.M.Sechenov
Awards
1978 Prize n.a.G.Lang by the Academy of Medical Sciences of USSR for the monograph on studies in Chronic circulatory insufficiency
1980 National award of USSR
1982 Medal for professional prowess
1990 Council of Ministers of Republic of Latvia award
1999 Memorable medal of academician Likhachev for significant contribution into development of clinical pharmacology
2004 Prize winner of the Mayor of Moscow award in medicine for development of the new drug “Prodetoxon” for treatment of drug addiction
2005 The order of Honour
2008 Russian government prize for achievements in science and technologies
2008 Russian Academy of Medical Sciences prize n.a. Kravkov for the best research work in pharmacology and toxicology
2009 Honorary badge and medal for achievements for the benefits of ethnic minorities
Other social and expert work:
Council from Russia in EACPT 1992-2002, i>collaboration with leaders in clinical pharmacology professors Michael Orme, Folke Sjoqvist, Ingolf Cascorbi, Ivar Roots, Vitan Vlahov and others
Founder and president of Association of clinical pharmacologists of Russia and Commonwealth of Independent States
Member of national formulary committee
Developer and co-author of the national guidelines on preclinical and clinical studies of medications
Teaching and methodological activities aiming at establishment and promotion of clinical pharmacology specialty
1970 developed the first in Russia teaching program in clinical pharmacology for medical students and physicians, and establishes the first teaching course in clinical pharmacology (future department of clinical pharmacology)
1982 successfully promoted introduction of clinical pharmacology courses in all medical institutes in Russia
1981, 1986 Author of the textbook for medical students in internal diseases, 2 editions
1997, 1999 Author of the first in Russia national position paper on “Medical specialty of clinical
pharmacology”
1991, 1999, 2003, 2006, 2008, 2014 Author of the textbook for medical students “Clinical pharmacology” – main recommended textbook in Russia, 5 editions
1999 Editor of the reference-book “Phitotherapy and basics of clinical pharmacology”
2003, 2008, 2013 Author of the textbook for pharmaceutical students “Clinical pharmacology and
pharmacotherapy” – 3 editions
Textbooks were translated into Spanish and Kazakh language.
2011, 2013 Author of the practical tutorial in clinical pharmacology for medical students and
doctors – 2 editions
2007 Editor of the textbook in clinical pharmacogenetics – 2007
2009 Editor of the textbook in clinical pharmacokinetics – 2009
2008 Author of the monograph “Metabolism of drugs: scientific basis of personalized
medicine”
Mentorship in clinical pharmacology dissertations
Candidate of medical sciences (relative equivalent of PhD) – 114, doctor of medical sciences – 25
Was a mentor in clinical pharmacology for current professors and heads of clinical pharmacology departments in Russia and countries of the Commonwealth of Independent States
Was a mentor in clinical pharmacology for students from all Russian region, countries of the Commonwealth of Independent States, and other countries: China, Taiwan, Iran, Morocco.
Activities in establishment and development of clinical pharmacology as a scientific discipline
Developer and co-author of the national guidelines on preclinical and clinical studies of medications
Founder and head of the first in Russia laboratory of pharmacokinetics (1969)
Consultant and co-founder of the first in Russia laboratories of pharmacogenetics (starting in 2005) in Moscow, Yaroslavl, Voronezh.
Founder of the first in Russia research project in ethnic pharmacogenetics involving Vladivostok, Azerbaijan, Yakutsk, Kazakhstan, Kazan.
Director of the Center of clinical pharmacology at the Research Center of Expertise of Medical Devices and Medicines, Ministry of Health 1999-2015
Developer and co-author of the national guidelines on preclinical and clinical studies of medications
Founder and promoter of the concept of personalized medicine in Russia
Founder and director of the research center of technologies in clinical pharmacology and personalized medicine
1974 – associate member 1993 – full member of the Russian Academy of Sciences
Activities in drug development
Co-developer of new and generic medications: foridone (riodipine) – calcium channel blocker, orthophene (diclophenac) – NSAID, methiopril (ACE-inhibitor), quiditen anticholinergic), ethmozin, ethacizine- antiarrhithmics.
Co-investigator of pharmacokinetics and pharmacodynamics of new medications: arbidol (antiviral), nibentan (antiarrhythmic), proxadolole (adrenergic blocker), ethoxydol (antioxidant) and other
Research publications and editorial work
Member of the editorial boards of leading pharmacology journals in Russia
Author of over 400 research publications in Russian and international journals. 21 monographs, 52 guidelines and textbooks for students and doctors, 16 patented inventions.
Main research areas: all aspects of personalized medicine and clinical pharmacology,
mainly pharmacokinetics, pharmacodynamics, drug interactions, adverse drug
reactions, pharmacogenetic test development etc.

view original CV

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[wm_item title=”Publications”]

Articles

  1. KUKES VG, VOL’FSDORF NIu. [Two cases of idiosyncrasy to penicillin]. Klin Med (Mosk). 1958 Nov;36(11):146-7
  2. KUKES VG. [ON USE OF THE BLOCKING AGENT ALDOSTERONE]. Klin Med (Mosk). 1963 Jun;41:65-9
  3. KUKES VG, VLASOVA MN. PLASMA AND DIETARY VITAMIN C CONTENT OF NATIVE POPULATION OF THE SOVIET FAR NORTH. Fed Proc Transl Suppl. 1964 Jul­Aug;23:911-2
  4. Vasilenko VKh, Karapetian GN, Kukes VG. [The use of diuretic preparations in chronic circulatory insufficiency]. Klin Med (Mosk). 1966 Mar;44(3):144-51
  5. Kukes VG, Stepanova NP. [Chronic dissecting aneurysm of the thoracic aorta]. Klin Med (Mosk). 1966 Jan;44(1):83-7
  6. Kukes VG, Menishikov VV, Usvatova IYa, Bunatian AF, Potekaeva SA, Blistanova LS. [Comparative characteristics of several plasma rates, edema and ascitic fluids in patients with circulatory failure]. Scientific and practical conference.Tula.1966
  7. Sivkov II, Kukes VG, Blistanova LS. [On several electrolytic disturbances in patients with chronic circulatory insufficiency]. Kardiologiia. 1967 Nov;7(11):91-6
  8. Sivkov II, Kukes VG. [On the treatment of patients with resistant forms of circulatory insufficiency]. Sov Med. 1967 Apr;30(4):10-7
  9. Spesivtseva VG, Kukes VG, Slavutskaia FM, Rubin MP, Prokhorov VV. [Study of the liver by the scanning method in patients with heart defects and circulatory insufficiency]. Kardiologiia. 1968 Nov;8(11):120-6
  10. Kukes VG, Alkhazov BI, Blistanova LS. [On the problem of the mechanism of action of the diuretic preparation, Lasix]. Kardiologiia. 1968 Oct;8(10):95-101
  11. Kukes VG, Men’shikov VV, Usvatova IIa, Butanian AF, Potekaeva SA, Blistanova LS. [Some biochemical indices of the blood serum, edematous and ascitic fluids in patients with circulatory insufficiency]. Klin Med (Mosk). 1968 Jan;46(1):100-3
  12. Kukes VG, Sivkov II, Men’shikov VV, Gneushev ET, Vinogradova LA. [Secretion of aldosterone by the adrenal glands, its blood plasma concentration and urinary excretion of 3-oxo­aldosterone in patients with chronic circulatory insufficiency]. Kardiologiia. 1970 Oct;10(10):62­7
  13. Kukes VG, Men’shikov VV, Bass ZhZh, Shekhter IM, Anastas’ina GV. [Excretion of adrenal hormones in patients with congestive circulatory insufficiency]. Kardiologiia. 1970 Feb;10(2):72-8
  14. Kukes VG, Men’shikov VV, Petrunina LA. [Effect of hypertension on the renin­aldosterone system, renal circulation, glomerular filtration and electrolyte excretion in patients with chronic circulatory insufficiency]. Kardiologiia. 1970;10(4):113-20
  15. Men’shikov VV, Kukes VG, Gneushev ET, Rubin MP. [Determination of the secretory rate and concentration of aldosterone in blood plasma by means of 1,2-alpha-aldosterone-H3]. Lab Delo. 1970;9:547-51
  16. Sivkov II, Kukes VG, Kirichenko LL, Fedosova NS, Ishmaeva KA. [Miscleron in the treatment of patients with atherosclerosis of the coronary and cerebal vessels]. Sov Med. 1971 Sep;34(9):54-7
  17. Bogdanovich NK, Kukes VG. [Hypothalamo-hypophyseal neurosecretory system in chronic circulatory insufficiency]. Arkh Patol. 1971;33(8):48-54
  18. Lukicheva TI, Bol’shakova TD, Kukes VG, Men’shikov VV. [Some indices of the state of the sympathetic-adrenal system in patients with chronic circulatory insufficiency]. Sov Med. 1971;34(3):23-31
  19. Sivkov II, Kukes VG, Izmalkova NM. [Disorders of acid-base balance and their correction in patients with chronic circulatory insufficiency]. Sov Med. 1972 Nov;35(11):15-22.
  20. Kukes VG, Men’shikov VV, Sivkov II. [Functional state of the renin-hypertension­aldosterone system in chronic circulatory insufficiency]. Klin Med (Mosk). 1972 Nov;50(11):109-14
  21. Kukes VG, Sivkov II, Aleksa VI, Tsoi AN, Duranté TO. [Use of beta-adrenostimulators in patients with bronchial asthma]. Klin Med (Mosk). 1974 Dec;52(12):90-4
  22. Sivkov II, Kukes VG, Mamedova AD, Rozinov IuI, Mazii SA. [Certain problems of antiarrhythmia therapy in myocardial infarct]. Sov Med. 1974 Nov;(11):58-64
  23. Sivkov II, Fel’dman SB, Kukes VG, Shamota BK, Zisel’man SB. [Use of kinidin-duretter for the treatment and prevention of auricular fibrillation]. Kardiologiia. 1974 Oct;14(10):30-5
  24. Sivkov II, Kukes VG, Zisel’man SB, Chebyshev NS, Shedov VV. [Clinical use of certain beta-blockaders]. Klin Med (Mosk). 1974 Jun;52(6):51-6
  25. Sivkov II, Kukes VG. [Use of cardiac glycosides in chronic circulatory insufficiency]. Kardiologiia. 1975 Oct;15(10):52-8
  26. Spesivtseva VG, Frenkel’ VKh, Mamaeva GG, Sokolovskii GA, Kukes VG. [Evaluation of the effectiveness of anginine treatment of diabetic microangiopathies]. Sov Med. 1975 Jul;(7):42-5
  27. Kukes VG. [Treatment of chronic circulatory insufficiency]. Klin Med (Mosk). 1975 Jul;53(7):122-8
  28. Kukes VG, Kniazev MD, Vorobkov AI, Semenov VN, Abugov AM. [Coronary reserve and differentiated therapy of its disorder]. Kardiologiia. 1975 Jun;15(6):52-7
  29. Sivkov II, Kukes VG, Chistova VS, Zakharova LN, Lebedeva NA. [Changes in the protein and energy metabolism and their correction in patients with circulatory insufficiency]. Kardiologiia. 1975 Feb;15(2):17-22
  30. Menshikov VV, Kukes VG, Bass ZhZh, Bogdanovich NK, Bunamian AF. [State of the pituitary-adrenal system in patients with chronic circulatory insufficiency]. Ter Arkh. 1975;47(7):112-8
  31. Kukes VG, Kniazev MD, Borovkov AI, Semenov VN, Mamedova AD. [Experience with the use of izoptina]. Kardiologiia. 1975 Jan;15(1):97-101
  32. Kukes VG, Tsoi AN, Alkhazov AI, Sivkov SI. [Use of beta-stimulators in chronic ischemic heart disease with complete atrioventricular block complicated by congestive circulatory insufficiency]. Kardiologiia. 1976 Aug;16(8):53-8
  33. Kukes VG, Cherkashina TG, Semenov VN, Borisov VG, Borovkov AI. [Value of cordaron effect -a new coronaroactive agent]. Sov Med. 1976 Jul;(7):115-7
  34. Sivkov II, Kukes VG, Bol’shakova TD, Tsoi AN, Meshcheriakova SA. [Use of beta stimulators in chronic cardio-pulmonary insufficiency]. Sov Med. 1976 Apr;(4):65-70
  35. Kukes VG, Buianov VV, Semenov VN, Abugov AM, Borovkov AI. [Use of coronaroactive agents with beta-stimulating effect in ischemic heart disease]. Kardiologiia. 1976 Apr;16(4):88-93
  36. Kniazev MD, Kukes VG, Borovkov AI, Biorisov VG, Blistanova LS. [Management of patients with chronic ischemic heart disease following surgical aortocoronary bapass]. Klin Med (Mosk). 1977 Nov;55(11):93-7
  37. Kukes VG, Volkov RIu. [Certain problems of pharmacodynamics, pharmacokinetics and the use of cardiac glycosides]. Kardiologiia. 1977 Sep;17(9):135-42
  38. Spesivtseva VG, Mamaeva GG, Kukes VG, Kasabian IN. [Thrombocyte aggregation in patients with diabetes mellitus before and after treatment with prodectin]. Sov Med. 1977 Jun;(6):65-70
  39. Sivkov II, Kukes VG, Borisov VG, Rudakov MA, Blistanova LS. [Use of xanthinol nicotinate in patients with chronic ischemic heart disease]. Ter Arkh. 1977;49(1):30-3
  40. Sivkov II, Kukes VG. [Present principles of treatment of chronic ischemic heart disease]. Sov Med. 1977 Jan;(1):56-61
  41. Kukes VG, Durante TO, Aleksa VI, Tsoi AN. [Long-term use of sodium cromoglycate (intal) in infectious-allergic form of bronchial asthma]. Ter Arkh. 1977;49(9):67-70
  42. Kukes VG, Mashkovskii MD, Paskhina TS, Borisov VG, Shvarts GIa. [Mechanism of action and clinical effectiveness of the new Soviet-made drug parmidin in the treatment of arteriosclerosis and ischemic heart disease]. Kardiologiia. 1978 Oct;18(10):61-8
  43. Kukes VG, Sivkov II, Tsoi AN, Aleksa VI, Prozorova VK, Kasymzhanova RD. [Problems of berotek pharmacodynamics]. Sov Med. 1978 Jul;(7):108-12. Russian. No abstract available
  44. Kukes VG. [Evaluation of the pharmacodynamic action of drugs widely used in medical practice]. Klin Med (Mosk). 1978 Jul;56(7):130-7
  45. Golubiatnikova GA, Sokolovskii GA, Kukes VG, Abylaev Zh, Timakina AP, Podgornaia NN. [State of the microcirculation in diabetes mellitus (based on conjunctival biomicroscopic data)]. Sov Med. 1978 Jun;(6):41-7
  46. Kukes VG, Senik EA, Gneushev ET, Potekaeva SA, Milovanova NM. [Use of the preparation Essenciale in chronic ischemic heart disease]. Kardiologiia. 1978 Jun;18(6):79-82
  47. Sivkov II, Kukes VG, Aleksa VI, Il’ina LB. [Clinical aspects of protracted pneumonia]. Sov Med. 1978 Apr;(4):44-8
  48. Kukes VG, Buniatian AF, Tsoi AN, Aleksa VI, Durante TO. [Use of aerosol of a new hormonal drug “Bekotid” for treatment of bronchial asthma]. Ter Arkh. 1978;50(12):62-7
  49. Kukes VG, Lokhvitskii SV, Aleksa VI, Il’ina LB, Gusev NM. [Bronchoscopic sanitization in complex treatment of abscessed pneumonia]. Ter Arkh. 1978;50(3):58-62
  50. Kukes VG, Shvarts GIa, Milovanova NM, Chang WW, Zisel’man SB. [Efficacy of tiphen]. Sov Med. 1979 Nov;(11):10-3
  51. Kukes VG, Burian EF, Sekamova SM, Baganova ME, Iudakova TM. [Use of phosphaden in treating chronic ischemic heart disease]. Kardiologiia. 1979 Oct;19(10):73-5
  52. Kukes VG, Senik EA, Gneushev ET, Utlinskaia MG, Nasonov AS. [Study of pharmacodynamics and pharmacokinetics of clofibrate for the purpose of selection of optimal course of treatment of ischemic heart disease]. Ter Arkh. 1979;51(12):57-61
  53. Kukes VG. [Metabolic disorders and their correction in cardiovascular diseases]. Sov Med. 1979 Jan;(1):99-104
  54. Spesivtseva VG, Kasabian IN, Mamaeva GG, Kukes VG. [Use of trental and complamine in the microcirculatory disorders of diabetes mellitus]. Sov Med. 1980;(2):64-9. Russian
  55. Kukes VG, Zisel’man SB, Burian EF, Khang V, Kireeva NA. [Hemodynamic effects of nitroglycerin]. Klin Med (Mosk). 1981 Nov;59(11):22-5
  56. Bol’shakova TD, Kukes VG, Siluyanova VA, Burkashov AB, Sokova EV, Nasonov AS. Metabolic effects of catecholamines in athletes during bicycle exercise of different intensity. Hum Physiol. 1981 Jul-Aug;7(4):300-5
  57. Kukes VG, Gneushev ET, Utlinskaia MG, Burian EF, Starodubtsev AK. [Pharmacokinetic characteristics of lidocaine in patients with circulatory failure]. Farmakol Toksikol. 1981 Jul­Aug;44(4):447-50
  58. Kukes VG, Sychenikov IA, Burian EF, Os’kin VV. [Teaching clinical pharmacology at a medical school]. Sov Med. 1981;(8):85-7. Russian
  59. Kukes VG, Tsoi AN, Iatsenko IV, Sivkov SI, Burian EF. [Hemodynamic effects of glucagon, isoprenaline and dopamine in patients with congestive circulatory insufficiency]. Kardiologiia. 1982 Sep;22(9):62-6
  60. Kukes VG, Volkov RIu, Lepakhin VK, Shokhor VIa, Rumiantsev AS. [Relations between pharmacokinetics and pharmacodynamics of digoxin]. Farmakol Toksikol. 1982 May­Jun;45(3):97-100
  61. Gneushev ET, Starodubtsev AK, Kurapov AP, Kukes VG, Zisel’man SB. [Relation between pharmacodynamics and the pharmacokinetics of anti-arrhythmia agents]. Farmakol Toksikol. 1982 May-Jun;45(3):107-10
  62. Kukes VG, Zisel’man SB, Shustikova GB, Rumiantsev AS, Shagako EV. [Use of the new hypotensive agent Minipress (prazosin hydrochloride]. Kardiologiia. 1982 Mar;22(3):46-50
  63. Kukes VG, Siluianova VA, Popov SN, Sokova EV, Al’perovich BR. [Early diagnosis of the overexertion of the cardiovascular system in sportsmen]. Sov Med. 1982;(4):18-21
  64. Kukes VG, Burian EF, Zisel’man SB, Milovanova NM. [Pharmacodynamics and therapeutic efficacy of cyto-poppy in patients with respiratory insufficiency].Kukes VG, Smetnev AS, Ponomarenko EL, Burian EF, Starodubtsev AK. [A new Soviet drug, ethacizine, in the treatment of ventricular rhythm disorders]. Kardiologiia. 1983 Nov;23(11):45-7
  65. Kukes VG, Volkov RIu. [Principles of pharmacotherapy with cardiac glycosides]. Revmatologiia (Mosk). 1983 Apr-Jun;(2):65-9
  66. Kukes VG. [Pharmacotherapy with nonspecific activators of metabolism]. Klin Med (Mosk). 1983 Apr;61(4):14-8
  67. Kukes VG, Forova NM, Burian EF, Gneushev ET, Saprykina TD. [Mechanism of the effect of riboxin]. Sov Med. 1983;(2):84-6
  68. Kukes VG, Syrkina EA. [Various features of the diagnosis and treatment of cardiac arrhythmias during long-term heart rate monitoring]. Sov Med. 1983;(10):79-82
  69. Kukes VG, Volkov RIu. [Effect of hypothiazide on carbohydrate tolerance in long-term treatment of hypertension]. Sov Med. 1983;(6):12-5
  70. Katrukha SP, Shitov NN, Kukes VG. [Determination of plasma concentrations of acetoacetic and pyruvic acids by high pressure liquid chromatography]. Lab Delo. 1983;(7):33-7
  71. Kuz’min AI, Saprygina TV, Sulimov VA, Kukes VG, Makolkin VI. [Features of myocardial metabolism of adenylic nucleotides in patients with paroxysmal tachycardias]. Kardiologiia. 1984 Dec;24(12):55-62
  72. Kukes VG, Blinkov Il, Chekhmakina OV, Krivorotova SP, Karpenko EV. [Use of gastrozepin in erosive-ulcerative diseases of the stomach and duodenum]. Klin Med (Mosk). 1984 Jul;62(7):114-7. Russian
  73. Chebyshev NS, Sivkov II, Volynskii IuD, Kukes VG, Goloma VV. [Stress mobilization of the myocardium]. Grudn Khir. 1984 Jul-Aug;(4):42-5
  74. Kuz’min AI, Saprygina TV, Vakhliaev VD, Kukes VG, Syrkin AL. [Effect of myocardial ischemia on adenine nucleotide metabolism]. Kardiologiia. 1984 Jun;24(6):28-33
  75. Kukes VG, Rudakov AG. [Drug interaction]. Klin Med (Mosk). 1984 Jun;62(6):9-16
  76. Kuz’min AI, Kukes VG, Chekhmakina OV. [Pharmacokinetic characteristics of zixoryn used in single and multiple doses]. Farmakol Toksikol. 1984 May-Jun;47(3):108-14
  77. Gneushev ET, Ponomarenko EL, Kurapov AP, Kukes VG. [Pharmacokinetics of the new Soviet anti-arrhythmia preparation etacizin]. Farmakol Toksikol. 1984 Mar-Apr;47(2):52-4
  78. Kuz’min AI, Saprygina TV, Kukes VG. [Effect of maximal physical exertion on adenine nucleotide metabolism in sportsmen]. Fiziol Cheloveka. 1985 May-Jun;11(3):490-8
  79. Kukes VG, Turashvili GA, Zakharchenko VN, Larionov SM, Pokrovskaia TZh. [Effect of graded physical exercise on the state of blood rheology in highly qualified sportsmen]. Fiziol Cheloveka. 1985 May-Jun;11(3):486-9
  80. Shugushev KhKh, Gneushev ET, Smetnev AS, Kukes VG, Rozenshtraukh LV. [Comparison of the results of ethacizin pharmacodynamics and pharmacokinetics in a single intravenous administration]. Kardiologiia. 1985 Apr;25(4):32-5
  81. Kukes VG, Volkov RIu, Ibadova D, Shokhor VIa. [Results of the pharmacokinetic, pharmacodynamic and clinical studies of digoxin use]. Ter Arkh. 1985;57(12):59-62
  82. Kukes VG, Al’perovich BR, Rumiantsev AS. [Ergometric evaluation of corinfar, phenoptin, obsidan and 2% nitroglycerin ointment in exercise-induced stenocardia]. Sov Med. 1985;(6):9-12
  83. Kukes VG, Spasskii AV, Alkhazov AI, Rudakov AG, Zisel’man SB. [Use of estulic in patients with arterial hypertension]. Sov Med. 1985;(12):57-61
  84. Katrukha SP, Kukes VG. Derivatization of endogenous and exogenous compounds in plasma for high-performance liquid chromatographic analysis. J Chromatogr. 1986 Sep 19;365:105-10
  85. Katrukha SP, Karpenko EV, Davydov SM, Blinkov IL, Kukes VG. [Cimetidine pharmacokinetics]. Farmakol Toksikol. 1986 Sep-Oct;49(5):36-40
  86. Kukes VG, Al’perovich BR, Rumiantsev AS. [Comparative evaluation of nifedipine and propranolol in ischemic heart disease]. Sov Med. 1986;(1):65-8
  87. Kukes VG, Ibadova DN, Zisel’man SB, Rumiantsev AS, Mukimdzhanov II. [Pharmacodynamic effects of strophanthidin acetate]. Sov Med. 1986;(8):70-3
  88. Kukes VG, Shugushev KhKh, Gneushev ET, Ponomarenko EL, Kurapov AP. [Pharmacokinetics and pharmacodynamics of ethacizin]. Sov Med. 1986;(4):81-2
  89. Katrukha SP, Kalenikov EI, Zagrebin SV, Kukes VG. [Pharmacokinetic characteristics of propranolol in patients with a history of acute myocardial infarct]. Farmakol Toksikol. 1987 May-Jun;50(3):87-9
  90. Kukes VG, Ponomarenko EL, Starodubtsev AK. [Experience using ethacizine in myocardial infarct patients]. Kardiologiia. 1987 May;27(5):97-8
  91. Sivkov II, Kukes VG, Ibadova DN, Shokhor VIa, Otdelenov AV. [Pharmacodynamics, pharmacokinetics and side effects of cardiac glycosides]. Vestn Akad Med Nauk SSSR. 1987;(9):83-7
  92. Kukes VG, Spasskii AV, Tsoi AN, Blinkov IL, Karpenko EV. [Extracardiac systemic pharmacodynamic effects of estulic (guanfacine)]. Klin Med (Mosk). 1987 Jan;65(1):46-9
  93. Kukes VG, Sivkov II, Shagako EV, Otdelenov AV, Rumiantsev AS. [Pharmacodynamic effects of peripheral vasodilators]. Vestn Akad Med Nauk SSSR. 1987;(11):70-5
  94. Kukes VG, Blinkov IL, Starodubtsev AK, Fedorov EA, Beliakova GA. [Pharmacological testing of the system of biotransformation of xenobiotics]. Klin Med (Mosk). 1988 Feb;66(2):127-9
  95. Gertsik LG, Il’icheva VI, Kukes VG, Syrkina EA. [Premorbid characteristics and nature of the mental disorders in patients with neurocirculatory dystonia and heart rhythm disorders (clinico-psychological research)].Zh Nevropatol Psikhiatr Im S S Korsakova. 1988;88(4):116-22
  96. Kukes VG, Murashko VV, Iagunina MV, Volchenok VI, Pokryshkin VI. [Clinical pharmacology of the new Soviet anti-inflammatory preparation ortofen]. Ter Arkh. 1988;60(3):105-9
  97. Kukes VG. [Clinical pharmacology of beta-adrenoblockaders]. Farmakol Toksikol. 1989 Sep-Oct;52(5):120-7
  98. Kukes VG, Tsoi AN, Abrosimov AG, Nasyrov ShN, Belov AM. [Pharmacologic effects of peripheral vasodilators in patients with secondary pulmonary hypertension]. Klin Med (Mosk). 1989 May;67(5):52-6
  99. Kukes VG, Griaznov VV, Blistanova LS. [Hemoglobin affinity to oxygen and its correction with captopril in chronic cardiac insufficiency]. Kardiologiia. 1989 Apr;29(4):34-6. Russian
  100. Kukes VG, Kazarian AB, Sozinov VN, Paramonov LV, Kniazev RP. [Central effects of beta adrenergic receptor blockaders, obsidan and trasicor, in arterial hypertension]. Sov Med. 1989;(8):61-3
  101. Kukes VG, Nasyrov ShN, Volchenok VI, Toporova EA, Abdunazarov TA. [Pharmacodynamics, pharmacokinetics and clinical effectiveness of captopril in patients with hypertension]. Kardiologiia. 1990 Mar;30(3):28-32
  102. Kukes VG, Stebliukova IA, Kozlova TV, Kniazev RP, Khairetdinova NB. [Dosage of low­energy laser irradiation in acute disorders of cerebrovascular circulation]. Klin Med (Mosk). 1990 Jan;68(1):57-60
  103. Kukes VG, Tsoi AN, Stefadu EG, Gneushev ET, Kniazev RP, Gavrilenko LN. [The clinical pharmacology of a new Soviet preparation theopek]. Ter Arkh. 1990;62(1):67-70. Russian
  104. Tsoi AN, Bogovskii BP, Gavrilenko LN, Kushkenbaeva BE, Kukes VG.[A dose­concentration relationship study in different dosage regimens for theophylline preparations: intravenous for euphylline and peroral for prolonged-action forms]. Ter Arkh. 1990;62(9):22-5
  105. Kurapov AP, Nekrasova OV, Gneushev ET, Ryzhenkova AP, Kukes VG. [Ethmozine pharmacokinetics in liver insufficiency]. Sov Med. 1990;(5):34-6
  106. Nasyrov ShN, Shvarts GIa, Kukes VG, Faermark IF, Siubaev RD. [The effect of fenigidin (nifedipine) and verapamil on renin activity, the levels of ionized calcium and aldosterone in the blood plasma and on the hemodynamic indices of rats with spontaneous hypertension]. Farmakol Toksikol. 1990 Jan-Feb;53(1):32-5
  107. Sivkov II, Kukes VG, Kozlova TV, Stebliukova IA, Mitrofanov VA, Shaporova GI. [Side effects of intravenous laser therapy]. Sov Med. 1990;(12):52-4. Russian. No abstract available
  108. Kukes VG, Rumiantsev AS, Gneushev ET, Al’perovich BR, Svetyi LI, Nasyrov MN, Taratuta TV. [The clinical pharmacology and efficacy of the new Soviet calcium antagonist foridon]. Ter Arkh. 1990;62(10):138-42
  109. Kukes VG, Lemina EIu, Rumiantsev AS. [The interaction of drug agents]. Farmakol Toksikol. 1991 Mar-Apr;54(2):82-5
  110. Kukes VG, Gneushev ET, Mamedov TSh, Gneusheva IA. [Acebutolol and diacetolol: their binding to plasma proteins and erythrocytes and secretion with the saliva]. Farmakol Toksikol. 1991 Jan-Feb;54(1):53-5
  111. Kukes VG, Sokolova TV, Petrov IN. [The pharmacodynamics of the H+, K(+)-ATPase blocker omeprazole]. Eksp Klin Farmakol. 1993 Nov-Dec;56(6):21-2
  112. Kukes VG, Alekhin SN, Rumiantsev AS, Gneushev ET, Gushchin AS, Germanov DV. [The pharmacokinetic and pharmacodynamic characteristics of foridon during interaction with the metabolic oxidation inhibitor dopegit]. Eksp Klin Farmakol. 1993 Sep-Oct;56(5):38-41. Russian
  113. Kukes VG, Fazylov AV, Kirkin BV, Kurapov AP, Volchenok VI. [Theopek absorption efficiency in chronic diseases of the large intestine]. Eksp Klin Farmakol. 1993 Jul­Aug;56(4):46-7
  114. Kukes VG, Fazylov AV, Kirkin BV, Kurapov AP, Blinov IL. [The pharmacokinetic characteristics of theophylline in patients with chronic nonspecific intestinal diseases in relation to its routes of administration into the gastrointestinal tract]. Ter Arkh. 1993;65(2):52-4
  115. Tsoi AN, Bogovskii BP, Saprygina TV, Kniazev RM, Titova EV, Kukes VG. [The pharmacodynamics of theophylline (euphylline)]. Ter Arkh. 1993;65(8):36-40
  116. Kukes VG, Ignat’ev VI, Kurapov AP, Pavlov SS, Rumiantsev AS, Chil’tsov VV. [A pharmacokinetic study of korinfar-retard in monotherapy and in combination with cordanum and triampur in patients with arterial hypertension]. Eksp Klin Farmakol. 1994 Nov-Dec;57(6):50-2
  117. Kukes VG, Starodubtsev AK, Smirnov MV, Petrov IN. [The pharmacodynamic and hypotensive efficacy of proxodolol in an acute drug test on hypertension patients]. Eksp Klin Farmakol. 1994 May-Jun;57(3):45-7
  118. Tsoi AN, Kukes VG, Gavrilenko LN, Sadovnikova SF. [The evaluation of the efficacy and safety of dosed aerosols of ditek, berotek and bicromat]. Ter Arkh. 1994;66(3):24-8
  119. Tsoi AN, Gavrilenko LN, Kushkenbaeva BE, Kukes VG. [The relationship of the theophylline concentration in the saliva and the blood serum in patients with a broncho­obstructive syndrome]. Ter Arkh. 1994;66(8):42-4
  120. Kukes VG, Ignat’ev VG, Pavlov SS, Starodubtsev AK. [The pharmacokinetics of different drug forms of nifedipine when used singly and in a course as monotherapy and in combination with Cordanum and triampur preparations in patients with arterial hypertension]. Eksp Klin Farmakol. 1995 Nov-Dec;58(6):22-5
  121. Kukes VG, Shikh EV. [Clinico-pharmacological approaches to the use of lasix]. Anesteziol Reanimatol. 1995 Sep-Oct;(5):40-4
  122. Kukes VG, Shikh EV. [The use of Lasix in current medical practice]. Ter Arkh. 1995;67(6):71-2
  123. Kukes VG, Belitskaia RA, Dubova MN, Krasavina MIu, Posrednikova TA. [Clinico­pharmacologic aspects of the use of ofloxacin]. Antibiot Khimioter. 1996;41(9):39-42
  124. Kukes VG, Ignat’ev VG, Pavlova LI, Rumiantsev AS, Pavlov SS, Privalov AN, Chil’tsov VV. Klin Med (Mosk). 1996;74(2):20-3. Russian
  125. Metz R, Muth P, Ferger M, Kukes VG, Vergin H. Sensitive high-performance liquid chromatographic determination of arbidol, a new antiviral compound, in human plasma. J Chromatogr A. 1998 Jun 12;810(1-2):63-9
  126. Kukes VG. [Clinical pharmacokinetics: the basis of laboratory monitoring of drugs (lecture)]. Klin Lab Diagn. 1998 Mar;(3):25-32
  127. Igonin AA, Armstrong VW, Shipkova M, Kukes VG, Oellerich M. The monoethylglycinexylidide (MEGX) test as a marker of hepatic dysfunction in septic patients with pneumonia. Clin Chem Lab Med. 2000 Nov;38(11):1125-8
  128. Ol’rikh M, Kukes VG, Igonin AA. [Role of lidocaine metabolism studies in the diagnosis of liver diseases]. Klin Lab Diagn. 2000 Jul;(7):8-11
  129. Tarnuev VA, Radzievskii SA, Kukes VG, Semenova LG. [Use of traditional methods in medicine for treating moderately severe bronchial asthma]. Vopr Kurortol Fizioter Lech Fiz Kult. 2001 Jan-Feb;(1):23-5. Russian
  130. Tsoi AN, Arkhipov VV, Antonovskii IuA, Shoker S, Kukes VG. [Clinical and medicinal cost-effect assessment of effectiveness of empirical therapy of extra-hospital pneumonia in hospital setting]. Klin Med (Mosk). 2002;80(11):37-41
  131. Ramenskaya GV, Savchenko AY, Agafonov AA, Sychev DA, Andreev DA, Kukes VG. Pheno-and genotyping the prescription of drugs metabolized by CYP2D6.Bull Exp Biol Med. 2002 Aug;134(2):159-60
  132. Kukes VG, Shikh EV, Sychev DA, Bulaev VM, Ramenskaia GV. [Interaction of biologically active additives, containing medicinal plants with drugs]. Vopr Pitan. 2003;72(5):39-43
  133. Syrkin AL, Kukes VG, Poltavskaia MG, Andreev DA, Aref’eva AB, Teplonogova EV, Konova IA, Rykova MS. [Effect of beta-blockers metoprolol CR/XL and carvedilol on left ventricular contractility in patients with chronic low cardiac output]. Ter Arkh. 2003;75(9):73-7. Russian
  134. Kukes VG, Ostroumova OD, Mamaev VI, Batutina AM, Abakumov IuE, Zykova AA. [Efficacy and safety of different beta-blockers in patients with isolated systolic hypertension associated with diabetes mellitus and obstructive pulmonary diseases]. Ter Arkh. 2003;75(8):43­
  135. 7.
    135.
    Igonin AA, Kukes VG. [Principles of antibacterial therapy of sepsis]. Klin Med (Mosk). 2003;81(6):61-5
  136. Kukes VG, Sychev DA, Andreev DA, Golukhova EZ, Ostroumov EN, Dmitrieva IM. [Activity of myocardial sympathetic-adrenal system with various volume of viable myocardium in patients with chronic cardiac failure]. Ter Arkh. 2004;76(2):49-52
  137. Igonin AA, Armstrong VW, Shipkova M, Lazareva NB, Kukes VG, Oellerich M. Circulating cytokines as markers of systemic inflammatory response in severe community­acquired pneumonia. Clin Biochem. 2004 Mar;37(3):204-9
  138. Kukes VG, Bulaev VM, Sychev DA, Shikh EV. [Safety of food supplements containing plant components]. Vopr Pitan. 2005;74(4):22-6
  139. Sychov DA, Kropacheva ES, Ignat’ev IV, Bulytova IuM, Dobrovol’skii AB, Panchenko EP, Kukes VG. [Pharmacogenetics of indirect anticoagulants: value of genotype for improvement of efficacy and safety of therapy]. Kardiologiia. 2006;46(7):72-7. Review. Russian
  140. Sychev DA, Kukes VG, Shikh EV, Bulaev VM, Ramenskaia GV, Kolkhir SV. [Clinical significance of the pharmacokinetic interactions between drugs and phytopreparations]. Eksp Klin Farmakol. 2006 Mar-Apr;69(2):75-9
  141. Sychev DA, Ramenskaia GV, Ignat’ev IV, Smirnikhina SA, Kazakov RE, Kukes VG. [The clinical pharmacology of beta-adrenoblockers]. Klin Med (Mosk). 2006;84(3):4-9
  142. Kukes VG, Sychev DA, Gasanov NA. [Present-day problems of clinical pharmacogenetics]. Klin Med (Mosk). 2007;85(2):58-63. Review. Russian
  143. Sychev DA, Mikheeva IuA, Kropacheva ES, Ignat’ev IV, Bulytova IuM, Ramenskaia GV, Dobrovol’skii AB, Panchenko EP, Kukes VG. [The influence of CYP2C9 genetic polymorphism on the pharmacokinetics and pharmacodynamics of warfarin in patients with constant atrial fibrillation]. Klin Med (Mosk). 2007;85(1):57-60
  144. Nazimkin KE, Kukes VG. [Active prospective monitoring of pharmacotherapy safety in outpatients: practical value]. Antibiot Khimioter. 2008;53(11-12):39-43
  145. Metz R, Muth P, Ferger M, Kukes Savel’eva MI, Sychev DA, Kazakov RE, Ignat’ev IV, Tishenova A, Gasanov NA, Ramenskaia GV,Kukes VG. [Importance of genetic polymorphism of cytochrome P450 isoenzymes for the choice and regimes of antidepressant and antipsychotic dosing on an individual basis]. Klin Med (Mosk). 2008;86(11):22-8
  146. Savel’eva MI, Sychev DA, Kazakov RE, Ignat’ev IV, Tishenova A, Gasanov NA, Ramenskaia GV,Kukes VG. [Importance of genetic polymorphism of cytochrome P450 isoenzymes for the choice and regimes of antidepressant and antipsychotic dosing on an individual basis]. Klin Med (Mosk). 2008;86(11):22-8
  147. Litvitskii PF, Kukes VG, Surnakova NE. [Changes of human immunophenotype during adaptation to environmental factors, in different forms of pathology and their specific treatment]. Vestn Ross Akad Med Nauk. 2008;(11):3-10
  148. Dmitriev VA, Sychev DA, Kukes VG. [Problem of antibiotic interaction with nonsteroid antiinflammatory agents (minireview)]. Antibiot Khimioter. 2008;53(1-2):30-2
  149. Beautiful Study Group., Ferrari R, Ford I, Fox K, Steg PG, Tendera M. The BEAUTIFUL study: randomized trial of ivabradine in patients with stable coronary artery disease and left ventricular systolic dysfunction -baseline characteristics of the study population. Cardiology. 2008;110(4):271-82
  150. Semenov SN, Chilova RA, Dmitriev VA, Anikin GS, Sychev DA, Kukes VG. [Interaction of antifungals with other drugs: clinical significance]. Antibiot Khimioter. 2008;53(7-8):40-3
  151. Larina SN, Ignat’ev IV, Chebyshev NV, Kukes VG. [Nuclear receptors and metabolism of xenobiotics]. Antibiot Khimioter. 2009;54(3-4):42-8
  152. Sychev DA, Nizovtseva OA, Anikin GS, Burian EF, Butiakova IV, Ignat’ev IV, Serebrova SIu, Guzhev DA, Dmitriev VA, Kukes VG. [A case of gastrointestinal hemorrage due to warfarin interaction with nalidixic acid resulting in massive blood loss]. Antibiot Khimioter. 2009;54(3-4):38-41
  153. Kukes VG, Kondratenko SN, Savelyeva MI, Starodubtsev AK, Gneushev ET. Experimental and clinical pharmacokinetics of amitryptiline: comparative analysis. Bull Exp Biol Med. 2009 Apr;147(4):434-7
  154. Sychev DA, Antonov IM, Ignat’ev IV, Naumova IuV, Dmitriev VA, Kropacheva ES, Dobrovol’skii OB, Panchenko EP, Tashenova IA, Kukes VG. [Anticoagulant action and safety of warfarin dosing based on pharmacogenetic testing: results of the first Russian prospective pilot study]. Kardiologiia. 2010;50(5):42-6. Russian
  155. Shumiantseva VV, Shikh EV, Makhova AA, Bylko TV, Kukes VG, Sizova OS, Ramenskaia GV, Usanov SA, Archakov AI. The influence of vitamin B group on monooxygenase activity of cytochrome P450 3A4: pharmacokinetics and electro analysis of catalytic properties. Biomed Khim. 2011 May-Jun;57(3):343-54
  156. Shohin IE, Kulinici II, Ramenskaya GV, Kukes VG. [The most important biopharmaceutical properties of drugs in absorption phase in TGI]. Himiko-pharm. journal, 2011..7. ..37-40
  157. Sychev DA, Ignat’ev IV, Kropacheva ES, Emel’ianov NV, Milovanova VV, Naumova IuA, Kosovskaia AV, Dobrovol’skii OB, Tashenova AI, Panchenko EP, Kukes VG. [CYP2C9 and VKORC1 gene polymorphism and acenocoumarol anticoagulant activity in Russian patients at high risk of thromboembolic complications]. Vestn Ross Akad Med Nauk. 2011;(3):7-10
  158. Sychev DV, Ignatyev IV, Emelyanov NV, Milovanova VV, Kossovskaya AV, Kukes IV, Tashenova AI,Kukes VG. CYP2C9 and VKORC1 gene polymorphism is inessential for bleeding development under conditions of oral application of anticoagulant acenocoumarol in Russian patients at high risk of thromboembolic complications. Bull Exp Biol Med. 2012 Oct;153(6):886-8
  159. Kukes VG, Zhernakova NI, Gorbach TV, Romashchenko OV, Rumbesht VV. [Efficiency of mildronate in rats of different age with experimental-induced myocardial ischemia]. Vestn Ross Akad Med Nauk. 2013;(1):42-6
  160. Zhestovskaja AS, Kukes VG, Sychev DA. Personalized medicine: myth or reality? The position of Russian clinical pharmacologists. EPMA J. 2013 May 11;4(1):13. doi: 10.1186/1878­5085-4-13
  161. Kukes VG, Zhernakova NI, Gorbach TV, Romashchenko OV, Rumbesht VV. [Efficiency of trimetazidine treatment of experimental ischemic heart disease in age aspect]. Eksp Klin Farmakol. 2013;76(2):9-12
  162. Shumiantseva VV, Makhova AA, Bulko TV, Shikh EV, Kukes VG, Usanov SA, Archakov AI. [Role of antioxidants in electro catalytic activity of cytochrome P450 3A4. Biomed Khim. 2014 Mar-Apr;60(2):224-34
  163. Shumyantseva VV, Makhova AA, Bulko TV, Bernhardt R, Kuzikov AV, Shich EV, Kukes VG, Archakov AI. Taurine modulates catalytic activity of cytochrome P450 3A4. Biochemistry (Mosc). 2015 Mar;80(3):366-73
  164. Zagorodnikova Goryachkina K, Burbello A, Sychev D, Frolov M, Kukes V, Petrov V. Clinical pharmacology in Russia-historical development and current state. Eur J Clin Pharmacol. 2015 Feb;71(2):159-63. doi: 10.1007/s00228-014-1787-6
  165. Serebrova SYu, Prokofiev AB, Krasnih LM, Juravliova MV, Shih EV, Ramenskaya GV, Kukes VG, Arhipov VV, Romanov BK. [Duodenal reflux and pharmacological acid suppression as the factors limiting interchangeability of rabeprazole natrium preparations]. Lechashij vrac.2016. Feb. 2:55
  166. Kukes V, Zhestovskaya A, Nartissov Ya, Tyukina E, Sheshegova E. [Metabolic agents in the treatment of alcoholism and different central nervous diseases]. Vrac (Mosc). 2016. Mar.3:25-28
  167. Goroshko OA, Kukes VG, Prokofiev AB, Arkhipov VV, Demchenkova EY. [Clinico­pharmacological aspects of application of antioxidant drugs].Mejd. jurnal prikladnih I fundamentalnih issledovanii. 2016. 4-5:905-912
  168. Shikh E, Kukes V, Petunina N. [Kokarnit: an analgesic potential in the treatment of diabetic polyneuropathy].Vrac (Mosc).2016. 4:20-26
  169. Kukes VG, Prokofiev AB, Checha OA, Goroshko OA, Mazerkina IA, Demchenkova EYu. [The effect of antioxidants on oxygen tension in the blood in patients with chronic heart failure]. Mejd. jurnal prikladnih i fundamentalnih issledovanii. 2016. 6-1:56-58
  170. Zhuravleva MV, Kukes VG,Prokofiev AB, Serebrova SYu, Gorodetskaya GI, Berdnikova NG.[Rational use of NSAIDs-balance of efficiency and safety (review)]. Mejd. jurnal prikladnih i fundamentalnih issledovanii. 2016. 6-4: 687-696
  171. Kukes V, Zhestovskaya A. [Non-steroidal anti-inflammatory drugs: current use and new perspectives]. Sportivnaja medicina.:nauka i practica (Mosc). 2016. 6.1(22):51-56
  172. Kukes VG, Reikhart DV, Arnautov VS, Torshina EV, Kapashin AV, Belostotskii AV. [Comparative study of Tizanidine Bioaccessibility in three medicinal forms].Himiko­pharnacevticeskii jurnal. 2016. 50.6:26-35
  173. Rodina TA, Melnikova ES, Psarev NA, Sokolov AV Arhipov VV, Pozdnyakov DL, Kukes VG.[Simultaneous determination of clomipramine and amitriptyline in human serum using HPLC-MS/MS].Biomedicina 2016. 1:43-51
  174. Goroshko OA, Novikov KN, Kukes VG, Voeikov VL, Arkhipov VV, Buravlev EV, Berdnikova NG, Zhestovskaya AS.[Correction of oxidative stress in patients with chronic cerebral ischemia]. Clin. Medicina. 2016. 94.7:549-553
  175. Gorodetskaya GI, Arkhipov VV, Zhuravleva MV, Kukes VG, Prokofiev AB, Rodina TA, Serebrova SYu, Sokolov AV, Shikh EV. [The interchangeability of the roxine sodium tablets]. Mejd. jurnal prikladnih i fundamentalnih issledovanii. 2016. 9-3:357-364
  176. Rumyantsev NA, Sychev DA, Kukes VG. [The experience of use of pharmacogenetic testing for anticoagulant therapy individualization]. Novaja nauka:teoreticeskii i practiceskii vzgljad. 2016. 10-2:52-55
  177. Rumyantsev NA, Sychev DA, Kukes VG. [The experience of use of pharmacogenetic testing for hypolipidemic therapy individualization]. Novaja nauka:teoreticeskii i practiceskii vzgljad. 2016. 10-2:49-52
  178. Zhestovskaya A., Smirnov V, Prokofyev FB Kukes V, Sychev D. [Role of cytochrome P450 3A4 in the metabolism of drugs used to treat chronic heart failure]. Vrac.2016. 9:54-57
  179. Kukes VG, Prokofiev AB, Zhestovskaya AS, Smirnov VV. [Aldosterone secretion increase in patients with chronic heart failure and ways of its normalization].Kliniceskaya farm i terapiya. 2016.25.3:64-66

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